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Exhaled Breath Condensate (EBC) offers a well-tolerated, non-invasive means of sampling that reflects the current status of the lungs and, by extension, the bloodstream. In the field of toxicology, EBC is instrumental in detecting a range of toxicological stressors. These include both endogenous and exogenous volatile organics, inflammatory markers, proteins, inorganic particulates, pathogens, and their associated toxins.  Using EBC, researchers can effectively monitor exposure to harmful conditions, narcotics, or environmental pollutants [7].

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Pharmacology

In pharmacology, EBC is a powerful tool for understanding how pharmaceuticals circulate and are metabolized within the body. Traces of these compounds present in EBC can be analyzed to assess the pharmacokinetics of various drugs, providing insights into how medications are processed and interact under varying physiological conditions [8].

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7. Pleil, J. D. (2016). Breath biomarkers in toxicology. Archives of Toxicology, 90(11), 2669–2682. https://doi.org/10.1007/s00204-016-1817-5

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8. López-Lorente, C. I., Awchi, M., Sinues, P., & García-Gómez, D. (2021). Real-time pharmacokinetics via online analysis of exhaled breath. Journal of Pharmaceutical and Biomedical Analysis, 205, 114311. https://doi.org/10.1016/j.jpba.2021.114311

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