VosBio™ has developed optimized molecular detection assays using Loop-mediated isothermal AMPlification (LAMP).  The LAMP reaction takes place at a constant temperature using a combination of 6 oligonucleotides that bind to the target sequence at 8 binding sites.  This technology allows for detection of nucleic acids in a way that is rapid, selective, and sensitive.

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Because of LAMP’s speed and sensitivity, it is well suited to be paired with rapid Exhaled Breath Condensate (EBC) collection.  VosBio’s SARS-CoV-2 assay has demonstrated the ability to detect 20 copies of virus in a 50 μL sample of EBC consistently under 30 minutes, and 200 copies within 15 minutes.

 

Because the reaction takes places at a constant temperature, it can be carried out in a relatively simple instrument, making it useful for testing in the field and at the point of need.